Developmental basis of natural tooth shape variation in cichlid fishes.

ABSTRACT: While most dentate non-mammalian vertebrates possess simple conical teeth, some demonstrate complex tooth shapes. Lake Malawi cichlid fishes are an extreme example of this, exhibiting a myriad of tooth shapes driven by an ecologically derived rapid evolution of closely related but distinct species. Tooth shape in mammals is generally considered to be established by signaling centers called primary and secondary enamel knots, which are not believed to be present in non-mammalian vertebrates. In this study, signaling centers of gene expression with epithelial folding with similar molecular patterns to that of mammalian enamel knots are identified, and differences of asymmetric gene expression are identified between fish that possess species specific polymorphisms of either bicuspid or tricus

SUBMITTER: Bloomquist RF 

PROVIDER: S-EPMC11772509 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature