Systematic Mendelian Randomization Exploring Druggable Genes for Hemorrhagic Strokes.

ABSTRACT: Patients with hemorrhagic stroke have high rates of morbidity and mortality, and drugs for prevention are very limited. Mendelian randomization (MR) analysis can increase the success rate of drug development by providing genetic evidence. Previous MR analyses only analyzed the role of individual drug target genes in hemorrhagic stroke; therefore, we used MR analysis to systematically explore the druggable genes for hemorrhagic stroke. We sequentially performed summary-data-based MR analysis and two-sample MR analysis to assess the associations of all genes within the database with intracranial aneurysm, intracerebral hemorrhage, and their subtypes. Validated genes were further analyzed by colocalization. Only genes that were positive in all three analyses and were druggable were considered

SUBMITTER: Yang LZ 

PROVIDER: S-EPMC11772512 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature