Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues.

ABSTRACT: Visualizing mechanical stress distribution in soft and live biomaterials is essential for understanding biological processes and improving material design. However, it remains challenging due to their complexity, dynamic nature, and sensitivity requirements, necessitating innovative techniques. Since polysaccharides are common in various biomaterials, a biosensor integrating a Förster resonance energy transfer (FRET)-based tension sensor module and carbohydrate-binding modules (FTSM-CBM) has been designed for real-time monitoring of the stress distribution of these biomaterials. By simple dripping or soaking, FTSM-CBM enables fast, reproducible and semiquantitative detection of both 2D and 3D stress distributions in polysaccharide-based hydrogels. Additionally, it provides valuable informa

SUBMITTER: Yuan F 

PROVIDER: S-EPMC11772616 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature