Mitochondrial calcium uniporter complex controls T-cell-mediated immune responses.

ABSTRACT: T-cell receptor (TCR)-induced Ca²⁺ signals are essential for T-cell activation and function. In this context, mitochondria play an important role and take up Ca²⁺ to support elevated bioenergetic demands. However, the functional relevance of the mitochondrial-Ca²⁺-uniporter (MCU) complex in T-cells was not fully understood. Here, we demonstrate that TCR activation causes rapid mitochondrial Ca²⁺ (_mCa²⁺) uptake in primary naive and effector human CD4⁺ T-cells. Compared to naive T-cells, effector T-cells display elevated _mCa²⁺ and increased bioenergetic and metabolic output. Transcriptome and proteome analyses reveal molecular determinants involved in the TCR-induced functional reprogramming an

SUBMITTER: Shumanska M 

PROVIDER: S-EPMC11772621 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature