Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomization.

ABSTRACT:

Objectives

This study aims to use Mendelian randomisation to identify the causal relationship between a spectrum of 41 inflammatory cytokines and the development of oropharyngeal cancer.

Methods

This study investigated genetic variants that have been associated with oral and oropharyngeal cancer using data from a large GWAS. Inflammatory cytokine data were obtained from 8293 asymptomatic individuals. The study primarily used inverse variance weighted and MR-Egger methods to determine the causal relationship between inflammatory cytokines and cancer incidence, complemented by a series of sensitivity analyses including MR-Egger, simple mode, weighted mode, weighted median and leave-one-out approaches.

Results

Our study demonstrates that higher levels of interleukin-7 (I

SUBMITTER: Xu S 

PROVIDER: S-EPMC11772633 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature