AURKB affects the proliferation of clear cell renal cell carcinoma by regulating fatty acid metabolism.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer with a high metastatic rate and high mortality rate. The molecular mechanism of ccRCC development, however, needs further study. Aurora kinase B (AURKB) functions as an important oncogene in various tumors; therefore, in the present study, we aimed to explore the mechanism by which AURKB affects ccRCC development.

Methods

We performed bioinformatics analysis, CCK-8 assay, RNA sequencing, RT-PCR and Western blot to analyze the function and mechanism of AURKB in ccRCC.

Results

TIMER2.0 showed that AURKB was overexpressed in Kidney Renal Clear Cell Carcinoma (KIRC), the UALCAN database showed the survival rate of KIRC patients with different expression levels of AURKB and diffe

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11772637 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature