Alzheimer's disease plasma biomarkers and physical functioning in a diverse sample of adults.

ABSTRACT:

Introduction

The relationship between Alzheimer's disease (AD) plasma biomarkers, and physical functioning (PF) across diverse races and ethnicities remains unclear. This study aims to explore this association in an ethno-racially diverse sample of cognitively unimpaired community-dwelling adults.

Methods

Data clinical examinations, neuropsychological tests, blood draws, and PF exams (Timed Up and Go [TUG] and Short Physical Performance Battery [SPPB]) were analyzed. Multivariable linear regressions assessed the association between PF and AD plasma biomarkers (amyloid beta [Aβ]40, Aβ42, total tau [t-tau], neurofiliament light chain [NfL]).

Results

The sample (n = 2358; mean age 64.7 years; 65.9% female), was 20% African American, 41.9% non-Hispanic White, and 38.1% Hi

SUBMITTER: Knell G 

PROVIDER: S-EPMC11772697 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature