Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.

ABSTRACT:

Introduction

Older adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with MCI and memory impairment.

Methods

One hundred sixty-one older adults free of dementia or major neurological/psychiatric disorders were recruited. Participants underwent clinical interviews, cognitive testing, venipuncture for Alzheimer's disease (AD) biomarkers, and brain magnetic resonance imaging. Spontaneous CVR was quantified during 5 minutes of rest. Respiratory gases analyzed through nasal cannula to quantify end-tidal carbon dioxide (_ETCO₂) levels were used to estimate CVR.

Results

Whole brain CVR was n

SUBMITTER: Engstrom AC 

PROVIDER: S-EPMC11772704 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature