Childhood adversity and late-life cognitive and brain health in a diverse cohort.

ABSTRACT:

Introduction

Childhood adversity harms neurodevelopment. Literature on late-life brain health is limited, and findings on late-life cognition are mixed.

Methods

Pooling data from Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) and Study of Healthy Aging in African Americans (STAR) cohorts, we assessed the impact of childhood adversity (factor score from seven self-reported items) on (a) executive function and verbal memory decline using linear mixed effects models (n = 2447), (b) structural magnetic resonance imaging (MRI) using linear regression (n = 618), and (c) amyloid positron emission tomography (PET) using generalized linear models (n = 331), all adjusting for early-life demographic and socioeconomic confounders.

Results

Childhood adversity was not

SUBMITTER: Hayes-Larson E 

PROVIDER: S-EPMC11772708 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature