Serum Urate and Atrial Fibrillation: A Bidirectional Mendelian Randomization Study.

ABSTRACT:

Background

Observational studies indicate that serum urate level is associated with atrial fibrillation (AF). However, whether this association is causal remains controversial, due to confounding factors and reverse causality. We aim to evaluate the causal relationship of genetically predicted serum urate level with AF.

Methods

A bidirectional Mendelian randomization (MR) study was performed. Instrumental variables were obtained from the Global Urate Genetics Consortium (110347 individuals). We obtained summary statistics of AF from two genome-wide association studies (GWAS) data sets for AF. Inverse-variance-weighted method was applied to obtain MR estimates and other statistical methods were conducted in the sensitivity analyses. The reverse MR analysis was performed to ev

SUBMITTER: Yu S 

PROVIDER: S-EPMC11772717 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature