Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum.

ABSTRACT:

Introduction

Alzheimer's disease (AD) typically involves both neurodegenerative and vascular pathologies, each associated with reductions in cerebral blood flow (CBF). However, it remains unclear whether vascular and neural contributions to regional CBF can be differentiated.

Methods

Using 3D background-suppressed arterial spin labeled perfusion magnetic resonance imaging, we evaluated regional CBF in a cohort of 257 participants across the AD continuum and assessed the impact of risk factors for both AD and small vessel disease (SVD) on regional CBF.

Results

Vascular risk factors (VRFs) were associated with reduced CBF in normal-appearing periventricular white matter, while amyloid positivity was associated with reduced CBF in the posterior cingulate cortex and precu

SUBMITTER: Taghvaei M 

PROVIDER: S-EPMC11772719 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature