Association of precuneus Aβ burden with default mode network function.

ABSTRACT:

Introduction

It remains unclear whether the local amyloid-beta (Aβ) burden in key regions within the default mode network (DMN) affects network and cognitive functions.

Methods

Participants included 1002 individuals from the Chinese Preclinical Alzheimer's Disease Study cohort who underwent 18F-florbetapir positron emission tomography resting-state functional magnetic resonance imaging scanning and neuropsychological tests. The correlations between precuneus (PRC) Aβ burden, DMN function, and cognitive function were investigated.

Results

In individuals with high PRC Aβ burden, there is a bidirectional relationship between DMN local function or functional connectivity and PRC Aβ deposition across various cognitive states, which is also linked to cognitive function. Eve

SUBMITTER: Cui L 

PROVIDER: S-EPMC11772721 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature