Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease.

ABSTRACT:

Introduction

Alterations in locus coeruleus' (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across disease stages and their functional relevance remains unknown.

Methods

We examined associations of [¹⁸F]-fluorodeoxyglucose positron emission tomography (FDG-PET) -derived LC metabolism with clinical diagnostic status, cerebrospinal fluid (CSF) -based AD biomarkers of AD pathology, and cognitive decline in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n = 604).

Results

FDG-PET-derived LC metabolism was elevated in the earliest preclinical stages and lower in later disease stages. Higher LC metabolism was associated with attenuated memory decline

SUBMITTER: Koops EA 

PROVIDER: S-EPMC11772725 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature