Metformin and Cognitive Performance in Patients With Type 2 Diabetes: An Umbrella Review.

ABSTRACT: Contradictory results for the association between metformin intake and changes in cognitive function have been reported. We attempted to overview systematic reviews and meta-analyses showing the role of metformin, as mono or combination therapy, in cognitive performance alterations among patients with type 2 diabetes mellitus (T2DM) and to determine the quality of the evidence as well. To find the English-written reviews, a literature search was conducted on PubMed, Web of Science, Scopus, Cochrane Library, Trip, and Google Scholar by May 1, 2023. The literature search unearthed 2672 records, 10 of which were included in the study. Metformin may provide cognitive benefits for patients with type 2 diabetes, as evidence suggests potential improvements in memory and a reduced risk of neurodeg

SUBMITTER: Enderami A 

PROVIDER: S-EPMC11772738 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature