Stem cells prevent long-term deterioration of renal function after renal artery revascularization in a renovascular hypertension model in rats.

ABSTRACT: Partial stenosis of the renal artery causes renovascular hypertension (RVH) and is accompanied by chronic renal ischemia, resulting in irreversible kidney damage. Revascularization constitutes the most efficient therapy for normalizing blood pressure (BP) and has significant benefits for renal function; however, the tissue damage caused by chronic hypoxia is not fully reversed. Mesenchymal stem cells (MSCs) have produced discrete results in minimizing RVH and renal tissue and functional improvements since the obstruction persists. This study aimed to evaluate the effects of administration of MSCs in combination with renal artery revascularization in rats subjected to RVH. The following groups were evaluated: control (SHAM), hypertensive (2K-1C), hypertensive treated with MSCs (MSC), hypert

SUBMITTER: Waack N 

PROVIDER: S-EPMC11772754 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature