Inhibition of transcriptional regulation of detoxification genes contributes to insecticide resistance management in Spodoptera exigua.

ABSTRACT: Synthetic insecticides have been widely used for the prevention and control of disease vectors and agricultural pests. However, frequent uses of insecticides have resulted in the development of insecticide resistance in these insect pests. The resistance adversely affects the efficacy of insecticides, and seriously reduces the lifespan of insecticides. Therefore, resistance management requires new strategies to suppress insecticide resistance. Here, we confirm that CncC/Maf are the key regulators of various detoxification genes involved in insecticide resistance in Spodoptera exigua. Then, we develop a cell screening platform to identify the natural compound inhibitors of CncC/Maf and determine that sofalcone can act as a CncC/Maf inhibitor in vitro and in vivo. Bioassay results showed tha

SUBMITTER: Hu B 

PROVIDER: S-EPMC11772755 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature