The Dystrophin-Dystroglycan complex ensures cytokinesis efficiency in Drosophila epithelia.

ABSTRACT: Cytokinesis physically separates daughter cells at the end of cell division. This step is particularly challenging for epithelial cells, which are connected to their neighbors and to the extracellular matrix by transmembrane protein complexes. To systematically evaluate the impact of the cell adhesion machinery on epithelial cytokinesis efficiency, we performed an RNAi-based modifier screen in the Drosophila follicular epithelium. Strikingly, this unveiled adhesion molecules and transmembrane receptors that facilitate cytokinesis completion. Among these is Dystroglycan, which connects the extracellular matrix to the cytoskeleton via Dystrophin. Live imaging revealed that Dystrophin and Dystroglycan become enriched in the ingressing membrane, below the cytokinetic ring, during and after rin

SUBMITTER: Goncalves M 

PROVIDER: S-EPMC11772804 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature