Preserved ratio impaired spirometry, airflow obstruction, and their trajectories in relationship to chronic kidney disease: a prospective cohort study.

ABSTRACT: Spirometry findings, such as restrictive spirometry and airflow obstruction, are associated with renal outcomes. Effects of spirometry findings such as preserved ratio impaired spirometry (PRISm) and its trajectories on renal outcomes are unclear. This study aimed to investigate the impact of baseline and trajectories of spirometry findings on future chronic kidney disease (CKD) events. This UK Biobank cohort study included participants with CKD who underwent spirometry at baseline (2006-2010). Lung function trajectories were determined using baseline and follow-up spirometry (2014-2020). Cox proportional hazards multivariate regression analysis was used to analyze the association between lung function and the incident CKD. In the baseline analysis (n = 282,354), fully adjusted hazard rati

SUBMITTER: Patel I 

PROVIDER: S-EPMC11772821 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature