Coordination of cytochrome bc₁ complex assembly at MICOS.

ABSTRACT: The boundary and cristae domains of the mitochondrial inner membrane are connected by crista junctions. Most cristae membrane proteins are nuclear-encoded and inserted by the mitochondrial protein import machinery into the inner boundary membrane. Thus, they must overcome the diffusion barrier imposed by crista junctions to reach their final location. Here, we show that respiratory chain complexes and assembly intermediates are physically connected to the mitochondrial contact site and cristae organizing system (MICOS) that is essential for the formation and stability of crista junctions. We identify the inner membrane protein Mar26 (Fmp10) as a determinant in the biogenesis of the cytochrome bc₁ complex (complex III). Mar26 couples a Rieske Fe/S protein-containing assembly inte

SUBMITTER: Zerbes RM 

PROVIDER: S-EPMC11772845 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature