Chinese herbal formula Tongxie Yaofang granules for diarrhoea-predominant irritable bowel syndrome: a randomised, double-blind, placebo-controlled, phase II trial.

ABSTRACT:

Objectives

To assess the therapeutic effects and safety of Tongxie Yaofang (TXYF) granules vs placebo as an alternative treatment for diarrhoea-predominant irritable bowel syndrome (IBS-D). We hypothesised that TXYF would improve clinical responses among patients with IBS-D.

Design

A randomised, double-blind, placebo-controlled, phase II, superiority trial.

Setting

Outpatients attending the Fangshan Hospital, Beijing University of Chinese Medicine, Beijing, China.

Participants

96 eligible participants included men and women ranging from late adolescence to middle adulthood (18-65 years), diagnosed with IBS-D according to the Rome IV criteria. In addition, they were required to have an irritable bowel syndrome symptom severity score (IBS-SSS) of at least 75.

SUBMITTER: Liang SB 

PROVIDER: S-EPMC11772933 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature