Legionella pneumophila subverts the antioxidant defenses of its amoeba host Acanthamoeba castellanii.

ABSTRACT: Legionella pneumophila, the causative agent of Legionnaires' disease, interacts in the environment with free-living amoebae that serve as replicative niches for the bacteria. Among these amoebae, Acanthamoeba castellanii is a natural host in water networks and a model commonly used to study the interaction between L. pneumophila and its host. However, certain crucial aspects of this interaction remain unclear. One such aspect is the role of oxidative stress, with studies focusing on reactive oxygen species (ROS) production by the host and putting less emphasis on the involvement of the host's antioxidant defenses during the infectious process. In this study, we propose to examine the consequences of infection with L. pneumophila wild-type or with an isogenic Δ

SUBMITTER: Hay A 

PROVIDER: S-EPMC11772960 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature