Transitions through the HIV continuum of care in people enrolling in care with advanced HIV disease in Latin America.

ABSTRACT:

Objectives

Advanced HIV disease (AHD) at HIV care enrollment is common in Latin America and may bias cross-sectional care continuum estimates. We therefore explored the impact of AHD on HIV care continuum outcomes using a longitudinal approach.

Methods

We analyzed trajectories of 26,174 adult people with HIV enrolled at Caribbean, Central and South America network for HIV epidemiology (CCASAnet) sites (2003-2019) using multi-state Cox regression across five stages: (i) enrolled without antiretroviral therapy (no-ART); (ii) on ART without viral suppression (viral load ≥200 copies/m; ART + non-VS); (iii) on ART with viral suppression (viral load <200 copies/ml; ART + VS); (iv) lost to follow-up; (v) death. We defined AHD as clusters of differentiation 4+ count <200 cells/µl an

SUBMITTER: Belaunzaran-Zamudio PF 

PROVIDER: S-EPMC11772978 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature