IS15DIV-flanked composite transposon harboring bla _NDM-5 in multidrug-resistant Salmonella Typhimurium.

ABSTRACT: Multidrug-resistant Salmonella Typhimurium has emerged as a global public health concern. Asymptomatic gastrointestinal carriage is a key factor in the spread of antibiotic-resistant bacteria. However, it is challenging to obtain direct evidence of in vivo transfer of mobile genetic elements (MGEs). Here, we found that MGEs harboring bla _NDM-5 were transferred from asymptomatic Escherichia coli (LS20223694) to Salmonella Typhimurium (LS20223695) in a child. BLAST analyses demonstrated that the IS15DIV-flanked composite transposon of pLS20223695_NDM5 showed high similarity with pLS20223694_NDM5 and two previously reported plasmids, suggesting the possibility of genetic recombination. Besides, conjugation experiments showed that the transc

SUBMITTER: Zhao K 

PROVIDER: S-EPMC11772981 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature