Short-term survivors with brain metastases have modest benefits from focal and systemic therapies and remain frequent despite improving treatment landscape.

ABSTRACT:

Purpose

Therapeutic options for patients with brain metastases (BM) increase. While these lead to considerable survival effects in subgroups, there is limited knowledge about characteristics, prognosticators and treatment effects in patients with BM and short survival.

Methods

Patients with a survival time of ≤ 6 months (short-term survivors, STS), diagnosed with BM between 2009-2021 at a large tertiary cancer center were analysed. Clinical and treatment characteristics, pathological data and causes of death were documented. Descriptive statistics, treatment-specific univariate Kaplan-Meier estimator analyses and multivariate Cox regression were performed.

Results

Among 1248 patients with BM, 480 (38 %) were STS. 256 STS with detailed clinical records were included in

SUBMITTER: Czogalla M 

PROVIDER: S-EPMC11772985 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature