Impact of tumor position displacement during end-exhalation breath-hold condition on tumor dose in lung stereotactic body radiation therapy using volumetric modulated arc therapy.

ABSTRACT:

Background and purpose

In lung stereotactic body radiation therapy (SBRT) using a breath-holding technique, displacement of tumor during breath-holding is rarely considered. This study used four-dimensional (4D) dose calculation with cine computed tomography (CT) to evaluate the impact of unexpected tumor position displacement during breath-holding on the target dose of lung volumetric modulated arc therapy (VMAT)-SBRT.

Materials and methods

This study included 20 cases for which tumor position displacement during end-exhalation breath-holding (range: 0.5-12.6 mm) was evaluated on cine CT. VMAT-SBRT plans (3D dose) were generated using treatment planning CT images (reference CT) acquired during end-exhalation breath-hold. For each plan, the 4D dose was calculated using defor

SUBMITTER: Kamima T 

PROVIDER: S-EPMC11772987 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature