Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice.

ABSTRACT:

Objective

The peroxisome proliferator-activated receptor-alpha (PPARα) plays a central role in lipid metabolism in the liver by stimulating the expression of hundreds of genes. Accordingly, regulation by PPARα could be a screening tool to identify novel genes involved in hepatic lipid metabolism. Previously, the mitochondrial transporter SLC25A47 was suggested to play a role in energy metabolism and liver-specific uncoupling, but further research is lacking.

Methods

We explored the potential role of SLC25A47 through in vitro studies and using mice overexpressing and lacking SLC25A47.

Results

SLC25A47 was identified as a PPARα-regulated and fasting-induced gene in human and mouse hepatocytes. Adenoviral-mediated overexpression of SLC25A47 minimally impacted metabolic p

SUBMITTER: Attema B 

PROVIDER: S-EPMC11773045 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature