Physiological arterial pressure improves renal performance during normothermic machine perfusion in a porcine kidney DCD model.

ABSTRACT:

Background

Normothermic machine perfusion (NMP) provides a platform for kidney quality assessment. Donation after circulatory death (DCD) donor kidneys are associated with great ischemic injury and high intrarenal resistance (IRR). This experimental study aims to investigate the impact of different perfusion pressures on marginal kidney function and injury during NMP.

Methods

Twenty-seven slaughterhouse porcine kidneys were retrieved and subjected to 60 min of warm ischemia time to mimic DCD condition. These kidneys were randomized into 75 mmHg (subphysiological, n = 9), 95 mmHg (physiological, n = 9), and 115 mmHg NMP (high physiological, n = 9). Renal function and injury were assessed during NMP.

Results

Three groups showed comparable IRR, with the 115 mmHg group ex

SUBMITTER: Fang Y 

PROVIDER: S-EPMC11773052 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature