Exploring the factors associated with difficulties in extracting tablets or capsules from press-through-package sheets.

ABSTRACT: Exploring factors related to difficulties in extracting tablets or capsules from press-through-packages is essential for optimizing the dosage form. To achieve this, the involvement of patient insight is important. In the present study, the preferences of patients regarding drugs that are difficult to extract from their packaging were collected using an electronic medication notebook ('harmo®') based on dispensing data. We found that approximately 30% of respondents had difficulty removing tablets or capsules from their packaging, with 125 specific drugs identified as 'hard to push out'. Independent factors related to 'hard-to-push-out' drugs were female sex and feeling of weakness in the hands or fingers. Furthermore, several 'hard-to-push-out' drugs had characteristics such as a spherica

SUBMITTER: Tsuchiya M 

PROVIDER: S-EPMC11773092 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature