Stabilisation of Bromenium Ions in Macrocyclic Halogen Bond Complexes.

ABSTRACT: Halenium ions (X⁺) are highly reactive electron deficient species that are prevalent transient intermediates in halogenation reactions. The stabilisation of these species is especially challenging, with the most common approach to sequester reactivity through the formation of bis-pyridine (Py) complexes; [(Py)₂X]⁺. Herein, we present the first example of a macrocyclic stabilisation effect for halenium species. Exploiting a series of bis-pyridine macrocycles, we demonstrate that preorganised macrocyclic ligands stabilise bromenium cations via endotopic complexation, impressively facilitating the isolation of a bench stable 'Br⁺ NO₃ ^-' species. Solid state X-ray crystallographic structural comparison of macrocyclic Br(I) compl

SUBMITTER: Docker A 

PROVIDER: S-EPMC11773099 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature