Meta-Dimethylation of Arenes via Catellani Reaction from Aryl Thianthrenium Salts.

ABSTRACT: Here we report the reaction of aryl thianthrenium salts that allows selective functionalization of the meta position of arenes. The combination of a site-selective thianthrenation with a Catellani reaction provides access to 3,5-dimethylated arenes. The developed reaction is complementary to the previously discovered reductive ipso-alkylation of aryl thianthrenium salts and extends the possibilities for late-stage methylation of arenes with a single aryl thianthrenium salt.

SUBMITTER: Mrozowicz M 

PROVIDER: S-EPMC11773114 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature