Heteroannulations of cyanoacetamide-based MCR scaffolds utilizing formamide.

ABSTRACT: C1 chemistry has a central role in the efficient utilization of single-carbon molecules, contributing significantly to sustainability, innovation and economic growth across various sectors. In this study, we present an efficient and rapid method for synthesizing a variety of heteroannulated pyrimidones using cyanoacetamide-based multicomponent reaction (MCR) chemistry. By utilizing specific MCR-based scaffolds as precursors and employing the abundant and inexpensive formamide as a C1 feedstock under neat conditions, we were able to efficiently access substituted thieno-, quinolino- and indolopyrimidones without the need of column chromatography. Further, a single-crystal X-ray structure was obtained, revealing certain geometrical features.

SUBMITTER: Zingiridis M 

PROVIDER: S-EPMC11773184 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature