Impact of Policy Changes Expanding Access to Direct-Acting Antivirals on Hepatitis C Virus-Related Hospitalizations in People With HIV: A Population-Based Study.

ABSTRACT:

Background

The burden of hepatitis C virus (HCV)-related hospitalizations is substantial, particularly among people with HIV and HCV. In Ontario, Canada, use of direct-acting antivirals (DAAs) increased following policies removing fibrosis-stage restrictions and approving of pangenotypic agents in 2017 and 2018, respectively. We examined the impact of expanded DAA access on HCV-related hospitalizations in people with HIV.

Methods

We conducted a population-based study using administrative databases between April 2003 and December 2022. We used segmented negative binomial regression to examine changes in level and trend of quarterly HCV-related hospitalization rates in people with HIV following the policy changes and compared predicted rates in the absence of expanded DAA acce

SUBMITTER: Antoniou T 

PROVIDER: S-EPMC11773189 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature