Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab.

ABSTRACT:

Background & aims

Atezolizumab/bevacizumab (A/B) is now a standard first-line treatment for advanced hepatocellular carcinoma (HCC), but the optimal second-line regimen is not known. We evaluated real-world treatment patterns and outcomes to investigate factors associated with post-progression survival (PPS).

Methods

In this multicenter, international, retrospective study, we examined clinical characteristics and outcomes of patients with advanced HCC who progressed on first-line A/B. The primary outcome of PPS was defined as time from first radiographic progression on A/B to death.

Results

A total of 406 patients alive after progression on first-line A/B were included in the final analysis, of whom 45.3% (n = 184) received best supportive treatment (BST) and 54.7% (n

SUBMITTER: Wu M 

PROVIDER: S-EPMC11773230 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature