Impact of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Lipoprotein(a): A Meta-Analysis and Meta-Regression of Randomized Controlled Trials.

ABSTRACT:

Background

Lipoprotein(a) [Lp(a)] has been independently associated with increased cardiovascular risk.

Objectives

The authors examined the effect of monoclonal antibody proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9is) on plasma Lp(a) levels across multiple trials.

Methods

Studies were retrieved comparing the effect of PCSK9i vs placebo on Lp(a) levels. The primary outcome was percent change in Lp(a) levels. Factors associated with the treatment effect were determined by meta-regression analysis. Subgroup analyses were done to explore potential treatment effect differences.

Results

PCSK9i reduced Lp(a) levels on average of -27% (95% CI: -29.8% to -24.1%, P < 0.001). Factors associated with the treatment effect included mean percent chan

SUBMITTER: Rivera FB 

PROVIDER: S-EPMC11773245 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature