Characterization of patients with clonal mast cells in the bone marrow with clinical significance not otherwise specified.

ABSTRACT:

Background

Systemic mastocytosis (SM) diagnosis requires the presence of 3 minor criteria or 1 major and 1 minor criterion according to the WHO 2016 classification. The aim of this study was to characterize patients with 1 or 2 minor SM criteria including KIT 816 mutation and/or aberrant expression of CD2 and/or CD25 on bone marrow (BM) mast cells (MCs), but without MC activation syndrome (MCAS) criteria.

Methods

We included eligible patients from two countries diagnosed between 2011 and 2021. These patients are reported herein as monoclonal MC with clinical significance (MMCS). MMCS patients were compared with 432 patients with indolent SM (ISM) and 51 with BM mastocytosis (BMM) from the CEREMAST database.

Findings

Overall, 51 patients with MMCS were included.

SUBMITTER: Ballul T 

PROVIDER: S-EPMC11773267 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature