Activation and C-C Coupling of Aryl Iodides via Bismuth Photocatalysis.

ABSTRACT: Within the emerging field of bismuth redox catalysis, the catalytic formation of C-C bonds using aryl halides would be highly desirable; yet such a process remains a synthetic challenge. Herein, we present a chemoselective bismuth-photocatalyzed activation and subsequent coupling of (hetero)aryl iodides with pyrrole derivatives to access C(sp²)-C(sp²) linkages through C-H functionalization. This unique reactivity is the result of the bismuth complex featuring two redox state-dependent interactions with light, which 1) activates the Bi(I) complex for oxidative addition via MLCT, and 2) promotes the homolytic cleavage of aryl Bi(III) intermediates through a LLCT process.

SUBMITTER: Mato M 

PROVIDER: S-EPMC11773318 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature