A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing.

ABSTRACT:

Background

Sarcopenia, characterized by a gradual decline in skeletal muscle mass and function with age, significantly impacts both quality of life and mortality. Autophagy plays a crucial role in maintaining muscle health. There is growing interest in leveraging autophagy to mitigate muscle ageing effects. The impact of natural autophagy activators on skeletal muscle ageing remains elusive. This study aims to identify natural autophagy activators and assess their effects on skeletal muscle ageing.

Methods

To discover novel autophagy activators, we screened 493 natural products and identified Castanea crenata flower extract (CCFE) as a promising candidate. We investigated the effect of CCFE on cellular senescence in C2C12 cells induced by etoposide. In animal experiments, ag

SUBMITTER: Park SH 

PROVIDER: S-EPMC11773338 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature