Comparative Efficacy of Nonsteroid Immunosuppressive Medications in Childhood Nephrotic Syndrome.

ABSTRACT:

Importance

Cyclophosphamide and calcineurin inhibitors are the most used nonsteroid immunosuppressive medications globally for children with various chronic inflammatory conditions. Their comparative effectiveness remains uncertain, leading to worldwide practice variation. Nephrotic syndrome is the most common kidney disease managed by pediatricians globally and suboptimal treatment is associated with high morbidity.

Objective

To evaluate the comparative effectiveness of cyclophosphamide vs calcineurin inhibitors (tacrolimus or cyclosporine) for childhood nephrotic syndrome relapse prevention.

Design, setting, and participants

Using target trial emulation methods, the study team emulated a pragmatic, open-label clinical trial using available data from the Insight Into

SUBMITTER: Robinson CH 

PROVIDER: S-EPMC11773402 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature