Predicting Individual Pain Sensitivity Using a Novel Cortical Biomarker Signature.

ABSTRACT:

Importance

Biomarkers would greatly assist decision-making in the diagnosis, prevention, and treatment of chronic pain.

Objective

To undertake analytical validation of a sensorimotor cortical biomarker signature for pain consisting of 2 measures: sensorimotor peak alpha frequency (PAF) and corticomotor excitability (CME).

Design, setting, and participants

This cohort study at a single center (Neuroscience Research Australia) recruited participants from November 2020 to October 2022 through notices placed online and at universities across Australia. Participants were healthy adults aged 18 to 44 years with no history of chronic pain or a neurological or psychiatric condition. Participants experienced a model of prolonged temporomandibular pain with outcomes collected o

SUBMITTER: Chowdhury NS 

PROVIDER: S-EPMC11773403 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature