Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences.

ABSTRACT: Learned action sequences are suggested to be organized hierarchically, but how the various hierarchical levels are processed by different cortical regions remains largely unknown. By training monkeys to perform heterogeneous saccade sequences, we investigated the role of the dorsolateral prefrontal cortex (DLPFC) and the lateral intraparietal cortex (LIP) in sequence planning and execution. The electrophysiological recording revealed that sequence-level initiation information was mostly signaled by DLPFC neurons, whereas subsequence-level transition was largely encoded by LIP neurons. Although electrical microstimulation on DLPFC weakly affected sequence performance, inactivating DLPFC significantly increased the initiation latency of the entire sequences, indicating that DLPFC was involve

SUBMITTER: Wang Q 

PROVIDER: S-EPMC11773476 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature