Versatile Stimuli-Responsive Controlled Release of Pinanediol-Caged Boronic Esters for Spatiotemporal and Nitroreductase-Selective Glucose Bioimaging.

ABSTRACT: Boronic acids have been widely applied in various biological fields, particularly achieving significant practical progress in boronic acid-based glucose sensing. However, boronic acids exhibit nonspecific binding to other nucleophiles, and the inherent lability of boronic esters in biological systems limits their further applications. Herein, we developed a stimuli-responsive controllable caging strategy to achieve photoresponsive spatiotemporally and nitroreductase-responsive cancer cell-selective glucose sensing. We introduced o-/p-nitroaryl-containing self-immolative linkers onto δ-pinanediol derivatives, effectively caging boronic acids and blocking glucose recognition. Upon triggering by specific stimuli, the caged boronic esters decompose, releasing boronic acids and th

SUBMITTER: Kao CY 

PROVIDER: S-EPMC11773560 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature