Uncovering Hericenones from the Fruiting Bodies of <i>Hericium erinaceus</i> through Interdisciplinary Collaboration.

ABSTRACT: Hericium erinaceus is an edible and medicinal mushroom. Previously, we found hericenones C-H from the fruiting bodies and erinacines A-I from the mycelia of the fungus. These compounds stimulated nerve growth factor (NGF) synthesis both in vitro and in vivo; some have been suggested to be effective in the prevention and treatment of dementia. Recently, the total synthesis of hericenones C-H and their derivatives (1-4) was reported by one of the authors. We considered that the chemical synthetic route would also be reasonable as a biosynthetic pathway of the compounds. Based on the hypothesis, we investigated the endogenous existence of synthetic intermediates and products of the chemical synthesis in the fruiting bodies. The n-hexane-soluble part o

SUBMITTER: Wang J 

PROVIDER: S-EPMC11773572 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature