Assessment of the quality of life in metastatic colorectal cancer patients with KRAS gene mutant: a case-control study.

ABSTRACT:

Background

The mutation of the KRAS (Kirsten rat sarcoma virus) gene is a prevalent genetic alteration in metastatic colorectal cancer (mCRC). According to previous research, this mutation significantly affects clinical outcomes and quality of life (QOL). This research investigated the association between KRAS mutant status and various aspects of QOL in mCRC patients.

Methods

This case-control study involved 90 admitted patients with mCRC. The patients were either mCRC with positive KRAS mutants (case group) or those without the mutation (control group). The KRAS mutation status of each patient was determined using standard molecular testing. The QOL was evaluated through validated questionnaires from the European Organization for Research and Treatment of Cancer (EORTC), in

SUBMITTER: Bagrezaei F 

PROVIDER: S-EPMC11773744 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature