The AhR pathway regulation in phthalates-induced cancer promotion, progression and metastasis: a scoping review.

ABSTRACT:

Background

Cancer remains a leading cause of death worldwide. Environmental factors, specifically endocrine-disrupting chemicals (EDCs), like phthalates, are increasingly being linked to cancer development. Phthalates, widely used in consumer products, can activate the aryl hydrocarbon receptor (AhR). This scoping review investigates how phthalate exposure influences cancer-related molecular pathways through the regulation of the AhR pathway to uncover the underlying mechanisms.

Methods

We conducted a comprehensive literature search in PubMed, Scopus, and Web of Science (ISI) database up to November 2023. Studies were selected based on peer-reviewed status, focus on phthalates' effects on cancer through the AhR pathway and the availability of full texts. Data extraction emph

SUBMITTER: Akbariani M 

PROVIDER: S-EPMC11773746 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature