ZNF169 promotes thyroid cancer progression via upregulating FBXW10.

ABSTRACT:

Background

Zinc finger protein 169 (ZNF169) plays a key role in cancer development. However, the specific role of ZNF169 in the tumorigenesis of thyroid carcinoma (THCA) remains poorly understood.

Methods

The expression of ZNF169 was measured using immunohistochemistry, RT-qPCR, and western blot. Cell proliferation was detected using CCK-8 assay and cell colony formation assays, while cell migration was determined by Transwell assay. Flow cytometry was used to detect cell apoptosis and cell cycle distribution. The interaction of ZNF169 and its downstream gene was studied using luciferase assay and CHIP-PCR. Recovery assay in cells and animals were also performed to demonstrate the mechanism.

Results

ZNF169 was highly expressed in THCA tissues and cells lines compared

SUBMITTER: Luo W 

PROVIDER: S-EPMC11773758 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature