The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer's disease mice.

ABSTRACT:

Background

Specific genetic variants in the ATP-binding cassette transporter A7 locus (ABCA7) are associated with an increased risk of Alzheimer's disease (AD). ABCA7 transports lipids from/across cell membranes, regulates Aβ peptide processing and clearance, and modulates microglial and T-cell functions to maintain immune homeostasis in the brain. During AD pathogenesis, neuroinflammation is one of the key mechanisms involved. Therefore, we wanted to investigate the specific role of ABCA7 in microglial activation via the NLRP3 inflammasome.

Methods

We developed the first humanized, Cre-inducible ABCA7^flx knock-in mouse model, crossbred it with the APPPS1-21 β-amyloidosis model, and generated constitutive ABCA7^ko and microglia Cx3cr1-specific conditiona

SUBMITTER: Santos-Garcia I 

PROVIDER: S-EPMC11773842 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature