NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway.

ABSTRACT: Chronic innate immune activation in the central nervous system (CNS) significantly contributes to neurodegeneration in progressive multiple sclerosis (MS). Using multiple experimental autoimmune encephalomyelitis (EAE) models, we discovered that NLRX1 protects neurons in the anterior visual pathway from inflammatory neurodegeneration. We quantified retinal ganglion cell (RGC) density and optic nerve axonal degeneration, gliosis, and T-cell infiltration in Nlrx1^-/- and wild-type (WT) EAE mice and found increased RGC loss and axonal injury in Nlrx1^-/- mice compared to WT mice in both active immunization EAE and spontaneous opticospinal encephalomyelitis (OSE) models. To minimize the effects of Nlrx1^-/- on peripheral lymphocyte priming during EAE, we performed

SUBMITTER: Gill AJ 

PROVIDER: S-EPMC11773851 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature