Pulmonary langerhans cell histiocytosis secondary to Marijuana use: a case report and systematic review of the literature.

ABSTRACT:

Background

Pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare interstitial lung disease primarily affecting young to middle-aged smokers. While traditionally linked to tobacco use, there is growing evidence that cannabis use may contribute to PLCH.

Methods

We present a case of a 52-year-old male with PLCH associated with heavy cannabis use. Diagnostic evaluations included CT scan of the chest and histopathological examination of a lung biopsy. In addition, a comprehensive review of the literature was conducted to identify and analyze similar cases of PLCH linked to cannabis use. Databases searched included PubMed and Google Scholar, following PRISMA guidelines.

Results

The patient presented with dyspnea, cough and unintentional weight loss. The patient had a 20-

SUBMITTER: Zahid I 

PROVIDER: S-EPMC11773874 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature