Risk of residual/recurrent cervical diseases in HPV-positive women post-conization depends on HPV integration status.

ABSTRACT:

Background

It is crucial to identify post-operative patients with HPV infection who are at high risk for residual/recurrent disease. This study aimed to evaluate the association between HPV integration and clinical outcomes in HPV-positive women after cervical conization, as well as to identify HPV integration breakpoints.

Methods

This retrospective study analyzed data of 791 women who underwent cervical conization for cervical intraepithelial neoplasia grades 2-3 (CIN2-3) between September 2019 and September 2023, sourced from the Fujian and Hubei cervical lesion screening cohorts. Among these, 73 women with HPV infection post-conization underwent HPV integration test within 3 months after a positive HPV test. HPV integration test was performed using the high-throughput vir

SUBMITTER: Lin W 

PROVIDER: S-EPMC11773928 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature