Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration.

ABSTRACT:

Background

The retinal degenerative diseases retinitis pigmentosa (RP) and atrophic age- related macular degeneration (AMD) are characterized by vision loss from photoreceptor (PR) degeneration. Unfortunately, current treatments for these diseases are limited at best. Genetic and other preclinical evidence suggest a relationship between retinal degeneration and inflammation. To further explore this relationship, we tested whether Ibuprofen (IBU), an FDA-approved non-steroidal anti-inflammatory drug (NSAID), could promote PR survival and function in a mouse model of light damage (LD)-induced PR degeneration.

Methods

LD was induced by exposing mice to 4000 lx of light for 2-4 hours (h). IBU (100 or 200 mg/kg) or vehicle was administered by daily intraperitoneal injection. Reti

SUBMITTER: Zhang PW 

PROVIDER: S-EPMC11773948 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature